IFN-a/b Receptor 1 Mouse anti-Mouse, NA/LE, Unlabeled, Clone: MAR1-5A3, BD

Description

• The MAR1-5A3 monoclonal antibody specifically binds to the IFN-α/β Receptor 1 (also known as Interferon-alpha/beta Receptor 1; Type I Interferon Receptor 1 or IFNAR-1) subunit
• A variety of cell types including lymphocytes, monocytes/macrophages, dendritic cells, and fibroblasts can be stimulated or induced by viral and microbial infections to produce and secrete type I interferons, including Interferon-alpha (IFN-α) subtypes and Interferon-beta (IFN- β)
• IFN-α subtypes and IFN-β bind to a common heterodimeric receptor complex (also known as the Type I IFN Receptor or IFN-α/β Receptor) that is comprised of transmembrane glycoprotein IFNAR-1 and IFNR-2 subunits and is expressed on most cell types
• Upon ligand binding, IFNAR-1 and IFNAR-2 signal cellular responses
• Type I interferons are multifunctional proteins that can induce antiviral states in cells as well as regulate the activation, growth, proliferation, differentiation and viability of various cell types including cells that mediate innate and adaptive immunity as well as autoimmune diseases
• The MAR1-5A3 monoclonal antibody blocks Type I IFN receptor signaling and in vitro and in vivo biologic responses caused by type I interferons
• The MAR1-5A3 antibody has also been reported to be useful for immunofluorescent staining and flow cytometric analysis, immunoprecipitation and Western blot analysis of IFNAR-1.