BDB562078
Stat6 (pY641) Mouse anti-Human, PE, Clone: 18/P-STAT6, BD
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB562078-Each-of-1 | In Stock | ₹ 1,22,350.80 |
BDB562078 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,22,350.80
GST (18%): ₹ 22,023.144
Total Price: ₹ 1,44,373.944
Antigen
Stat6 (pY641)
Classification
Monoclonal
Conjugate
PE
Formulation
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen
Phosphorylated Human Stat6 (pY641)
Quantity
250 Tests
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications
Flow Cytometry
Clone
18/P-STAT6
Description
Signal transducer and activator of transcription 6; IL-4 Stat
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a
Related Products
Description
- Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development
- It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641)
- Stat6, a member of the s ignal t ransducers and a ctivators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13
- While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta
- Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors
- The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain
- Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP
- Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity.
Compare Similar Items
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Antigen: Stat6 (pY641)
Classification: Monoclonal
Conjugate: PE
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Phosphorylated Human Stat6 (pY641)
Quantity: 250 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: 18/P-STAT6
Description: Signal transducer and activator of transcription 6; IL-4 Stat
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a
Antigen:
Stat6 (pY641)
Classification:
Monoclonal
Conjugate:
PE
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Phosphorylated Human Stat6 (pY641)
Quantity:
250 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
18/P-STAT6
Description:
Signal transducer and activator of transcription 6; IL-4 Stat
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a
Antigen: T- and B-Cell Activation Antigen
Classification: Monoclonal
Conjugate: FITC
Formulation: Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen: In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: GL7
Description: GL7
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgM κ
Antigen:
T- and B-Cell Activation Antigen
Classification:
Monoclonal
Conjugate:
FITC
Formulation:
Aqueous buffered solution containing protein stabilizer and ≤0.09% sodium azide.
Immunogen:
In vitro-activated T-cell-depleted CBA/Ca mouse splenocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
GL7
Description:
GL7
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgM κ
Antigen: TCR β Chain
Classification: Monoclonal
Conjugate: FITC
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Quantity: 25 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: H57-597
Description: __
Host Species: Hamster
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2 λ1
Antigen:
TCR β Chain
Classification:
Monoclonal
Conjugate:
FITC
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
TCR affinity-purified from mouse T-cell hybridoma DO-11.10
Quantity:
25 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
H57-597
Description:
__
Host Species:
Hamster
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2 λ1
Antigen: Vb 5.1, 5.2 TCR
Classification: Monoclonal
Conjugate: PE
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Mouse T-Cell Hybridoma 2HB51.8
Quantity: 25 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications: Flow Cytometry
Clone: MR9-4
Description: __
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG1 κ
Antigen:
Vb 5.1, 5.2 TCR
Classification:
Monoclonal
Conjugate:
PE
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Mouse T-Cell Hybridoma 2HB51.8
Quantity:
25 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Applications:
Flow Cytometry
Clone:
MR9-4
Description:
__
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG1 κ