BDB563019

Fcμ Receptor Mouse anti-Human, PE, Clone: HM7-10, BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB563019-Each-of-1 In Stock ₹ 16,085.28

BDB563019 - Each of 1

₹ 16,085.28

In Stock

Quantity

1

Base Price: ₹ 16,085.28

GST (18%): ₹ 2,895.35

Total Price: ₹ 18,980.63

Antigen

Fcμ Receptor

Classification

Monoclonal

Conjugate

PE

Formulation

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen

Human IgM Fc Receptor Transfected Cell Line

Quantity

50 Tests

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications

Flow Cytometry

Clone

HM7-10

Description

FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG2b κ

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Description

  • Description The HM7-10 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcµR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor)
  • The FcµR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fc α /µR and pIgR
  • It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems
  • FcµRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells
  • FcµRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity
  • The relatively long cytoplasmic tail of FcµR contains several conserved tyrosine and serine residues
  • These get phosphorylated after FcµR ligation with IgM immune complexes and may initiate signaling responses
  • Lymphocyte FcµRs can mediate the internalization of IgM-bound antigens including microbial and viral antigens
  • This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors
  • The HM7-10 antibody reportedly recognizes an epitope near the IgM ligand binding site of the FcµR whereas, a related FcµR-specific antibody, HM14-1 antibody does not
  • The HM7 epitope is sensitive to IgM ligand binding.

Compare Similar Items

Show Difference

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BD Biosciences

BDB563019

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Antigen:
Fcμ Receptor

Classification:
Monoclonal

Conjugate:
PE

Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen:
Human IgM Fc Receptor Transfected Cell Line

Quantity:
50 Tests

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications:
Flow Cytometry

Clone:
HM7-10

Description:
FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG2b κ

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Antigen:
TRA-1-85

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen:
Human Embryonal Carcinoma Cell Line

Quantity:
100 μg

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C

Applications:
Flow Cytometry

Clone:
TRA-1-85

Description:
OKa, CD147, EMMPRIN, Basigin

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG1 κ

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Classification:
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Conjugate:
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Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Immunogen:
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Quantity:
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Primary or Secondary:
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Content And Storage:
Store undiluted at 4°C

Applications:
Western Blot

Clone:
R11-560

Description:
Nkx6.1, NKX6-1, NKX6A, Nkx6-1, Nkx6.1, Nkx6a

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human, Mouse

Isotype:
IgG1 κ

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Antigen:
Nkx6.1

Classification:
Monoclonal

Conjugate:
PE

Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

Immunogen:
Human Nkx6.1 Recombinant Protein

Quantity:
50 Tests

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Applications:
Flow Cytometry

Clone:
R11-560

Description:
Nkx6.1, NKX6-1, NKX6A, Nkx6-1, Nkx6.1, Nkx6a

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human, Mouse

Isotype:
IgG1 κ