Fcμ Receptor Mouse anti-Human, PE, Clone: HM7-10, BD

Description

• Description The HM7-10 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcµR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor)
• The FcµR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fc α /µR and pIgR
• It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems
• FcµRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells
• FcµRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity
• The relatively long cytoplasmic tail of FcµR contains several conserved tyrosine and serine residues
• These get phosphorylated after FcµR ligation with IgM immune complexes and may initiate signaling responses
• Lymphocyte FcµRs can mediate the internalization of IgM-bound antigens including microbial and viral antigens
• This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors
• The HM7-10 antibody reportedly recognizes an epitope near the IgM ligand binding site of the FcµR whereas, a related FcµR-specific antibody, HM14-1 antibody does not
• The HM7 epitope is sensitive to IgM ligand binding.