BDB563535

Fcμ Receptor Mouse anti-Human, Alexa Fluor 647, Clone: HM14-1 (also known as HM14), BD

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB563535-Each-of-1 In Stock ₹ 22,074.48

BDB563535 - Each of 1

₹ 22,074.48

In Stock

Quantity

1

Base Price: ₹ 22,074.48

GST (18%): ₹ 3,973.406

Total Price: ₹ 26,047.886

Antigen

Fcμ Receptor

Classification

Monoclonal

Conjugate

Alexa Fluor 647

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1 κ

Applications

Flow Cytometry

Clone

HM14-1 (also known as HM14)

Description

FcμR; FcmR; Fc mu receptor; IgM Fc receptor; FAIM3; TOSO

Immunogen

Human IgM Fc Receptor Transfected Cell Line

Quantity

50 Tests

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

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Description

  • Description The HM14-1 monoclonal antibody specifically binds to the FAIM3 -encoded high affinity receptor for IgM (also known as, Fcµ Receptor, FcλR, Fc mu receptor, Immunoglobulin mu Fc receptor, FcmR, IgM Fc receptor)
  • The FcλR is a type 1 transmembrane glycoprotein that contains an extracellular Ig-like domain with sequence similarities to Fcα/λR and pIgR
  • It is likewise known as Fas apoptotic inhibitory molecule 3, TOSO or Regulator of Fas-induced apoptosis Toso based on its capacity to counter apoptosis mediated by Fas/CD95 (or TNF) in some experimental model systems
  • FcλRs are expressed by B cells, CD4+ T cells, CD8+ T cells, and NK cells and are highly expressed on Chronic Lymphocytic Leukemia cells
  • FcλRs may play roles in cellular activation, antigen presentation and IgM-dependent cell-mediated cytotoxicity
  • The relatively long cytoplasmic tail of FcλR contains several conserved tyrosine and serine residues
  • These get phosphorylated after FcλR ligation with IgM immune complexes and may initiate signaling responses
  • Lymphocyte FcλRscan mediate the internalization of IgM-bound antigens including microbial and viral antigens
  • This in turn may cause cellular activation due to subsequent antigen processing and exposure of activating ligands to intracellular receptors including Toll-like receptors
  • The HM7-10 antibody, a related FcμR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcμR whereas the HM14-1 antibody does not
  • oll-like receptors
  • The HM7-10 antibody, a related FcλR-specific antibody, reportedly recognizes an epitope near the IgM ligand binding site of the FcλR whereas the HM14-1 antibody does not.

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Antigen:
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RUO

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Human

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IgG1 κ

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Flow Cytometry

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Antigen:
__

Classification:
__

Conjugate:
__

Host Species:
__

Purification Method:
__

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__

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__

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__

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__

Clone:
__

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__

Immunogen:
__

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50 Tests

Primary or Secondary:
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