CD194 Mouse anti-Human, Brilliant Violet 510, Clone: 1G1, BD

Description

• The monoclonal antibody 1G1 reacts with CD194, also known as the human CC Chemokine Receptor type 4 (CCR4)
• CCR4 is expressed on activated Th2 cells, regulatory T cells, activated NK cells, basophils, monocytes and platelets
• CCR4 is a seven-transmembrane, G-protein-coupled receptor, and is the specific receptor for CC chemokines, CCL22/MDC/Macrophage-Derived Chemokine and CCL17/TARC/Thymus and Activation-Regulated Chemokine
• It has been reported that CCR4 mRNA is expressed mainly in the thymus and spleen
• The human CCR4 gene has been mapped to chromosome 3p24
• The purified form of this antibody has been reported not to be a neutralizing antibody
• The immunogen used to generate the 1G1 hybridoma has been reported to be human CCR4 transfected L1.2 mouse lymphoma cells
• The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon™ Brilliant Violet™ family of dyes
• With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon™ BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set
• BD Horizon™ BV510 conjugates are useful for the detection of dim markers off the violet laser.