BDB563533
Cutaneous Lymphocyte Antigen Rat anti-Human, Alexa Fluor 647, Clone: HECA-452, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563533-Each-of-1 | In Stock | ₹ 26,823.06 |
BDB563533 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 26,823.06
GST (18%): ₹ 4,828.151
Total Price: ₹ 31,651.211
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Description
- The HECA-452 monoclonal antibody specifically reacts with Cutaneous Lymphocyte Associated Antigen (CLA), a carbohydrate domain shared by sialyl Lewis[x] (sLe[x]) and sialyl Lewis[a] (sLe[a]) antigens
- It serves as a ligand for selectins including CD62E (E-selectin; ELAM-1)
- CLA is expressed on high endothelium and on lymphocytes including most T lymphocytes infiltrating cutaneous sites of inflammation
- Amongst peripheral blood cells, it is expressed on monocytes and granulocytes and a subset of lymphocytes
- The HECA-452 antibody is also reportedly crossreactive with the mouse CLA carbohydrate epitope that is transiently expressed by PSGL-1/CD162 on activated T cells
- A number of studies suggest that CLA plays an important role in supporting leucocyte adhesive interactions and migration into extravascular tissues during inflammation.