BDB563801
Helios Armenian Hamster , PE, Clone: 22F6, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB563801-Each-of-1 | In Stock | ₹ 24,427.38 |
BDB563801 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 24,427.38
GST (18%): ₹ 4,396.928
Total Price: ₹ 28,824.308
Antigen
Helios
Classification
Monoclonal
Concentration
0.2mg/mL
Description
IKAROS family zinc finger protein 2; ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Host Species
Armenian Hamster
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human, Mouse
Isotype
IgG
Applications
Flow Cytometry
Clone
22F6
Conjugate
PE
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen
Mouse Helios Peptide
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Related Products
Description
- The 22F6 monoclonal antibody specifically binds to mouse and human Helios
- Helios is a member of the Ikaros family of zinc-finger transcription factors, which play important roles in hematopoietic cell development and tumor suppression
- Helios expression is restricted to the earliest stages of embryonic hematopoiesis, a variety of epithelial tissues and is notably increased in thymic-derived regulatory CD4+Foxp3+ T (Treg) cells
- Its high expression levels in Treg cells are independent from Foxp3 and are believed to contribute, along with other transcription factors, to the phenotypic stability of natural regulatory T cells
- Accordingly, it has been demonstrated that Helios directly stimulates Foxp3 transcription while it inhibits ll2 gene expression, contributing for the maintenance of cellular anergy
- Helios is also differentially expressed during negative and positive selection in the thymus, marking CD4+ autoreactive cells for deletion
- Helios may possibly play roles in T cell activation, since it is upregulated in Th2 and Tfh cells
- Despite these roles in T cell development and function, Helios genetic ablation in mice revealed no significant abnormalities in Treg or other T cell subsets
- This finding suggests that other Ikaros family members may play redundant roles.
Compare Similar Items
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Antigen: Helios
Classification: Monoclonal
Concentration: 0.2mg/mL
Description: IKAROS family zinc finger protein 2; ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Host Species: Armenian Hamster
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human, Mouse
Isotype: IgG
Applications: Flow Cytometry
Clone: 22F6
Conjugate: PE
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen: Mouse Helios Peptide
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
Helios
Classification:
Monoclonal
Concentration:
0.2mg/mL
Description:
IKAROS family zinc finger protein 2; ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
Host Species:
Armenian Hamster
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human, Mouse
Isotype:
IgG
Applications:
Flow Cytometry
Clone:
22F6
Conjugate:
PE
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Immunogen:
Mouse Helios Peptide
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD62L
Classification: Monoclonal
Concentration: __
Description: SELL; L-selectin; LSEL; LAM-1; LECAM-1; LEU8; LNHR; MEL-14; PLNHR; TQ-1
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: DREG-56
Conjugate: Brilliant Violet 650
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Supernatant from PMA-activated Human Peripheral Blood Leukocytes
Quantity: 100 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD62L
Classification:
Monoclonal
Concentration:
__
Description:
SELL; L-selectin; LSEL; LAM-1; LECAM-1; LEU8; LNHR; MEL-14; PLNHR; TQ-1
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
DREG-56
Conjugate:
Brilliant Violet 650
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Supernatant from PMA-activated Human Peripheral Blood Leukocytes
Quantity:
100 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: CD235A
Classification: Monoclonal
Concentration: __
Description: Glycophorin-A; GYPA; GPA; PAS-2; MN sialoglycoprotein; Sialoglycoprotein A
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2b κ
Applications: Flow Cytometry
Clone: GA-R2 (HIR2)
Conjugate: Brilliant Ultraviolet 395
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: __
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
CD235A
Classification:
Monoclonal
Concentration:
__
Description:
Glycophorin-A; GYPA; GPA; PAS-2; MN sialoglycoprotein; Sialoglycoprotein A
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2b κ
Applications:
Flow Cytometry
Clone:
GA-R2 (HIR2)
Conjugate:
Brilliant Ultraviolet 395
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
__
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen: IgD
Classification: Monoclonal
Concentration: __
Description: IGHD; Ig delta chain C region; Immunoglobulin heavy constant delta
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: IA6-2
Conjugate: Brilliant Ultraviolet 395
Formulation: Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen: Human IgD
Quantity: 50 Tests
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Antigen:
IgD
Classification:
Monoclonal
Concentration:
__
Description:
IGHD; Ig delta chain C region; Immunoglobulin heavy constant delta
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
IA6-2
Conjugate:
Brilliant Ultraviolet 395
Formulation:
Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Immunogen:
Human IgD
Quantity:
50 Tests
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.