CD22 Mouse anti-Human, Brilliant Violet 421, Clone: HIB22, BD

Description

• The HIB22 monoclonal antibody specifically binds to CD22
• CD22 is a 130-140 kDa glycosylated type I integral membrane protein present on the surface of mature B cells
• CD22 is expressed in the cytoplasm of virtually all B cells except plasma cells
• CD45RO antigen on T cells and CD75 antigen on B cells have been identified as ligands for CD22
• CD22 has been reported to participate in B-cell activation and also as an adhesion molecule
• Although the immunobiology of this antigen has not been fully elucidated, reports indicate that ligation of CD22 induces constitutive internalization of the molecule followed by complete degradation
• The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 407-nm and Em Max at 421-nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50-nm filter)
• BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue™ conjugates.