Delta-Like Protein 4 Mouse anti-Human, PE, Clone: MHD4-46, BD

Description

• The MHD4-46 monoclonal antibody specifically binds to Delta-Like Protein 4 which is also known as Delta4, DLL4, and DL4
• Delta-Like Protein 4 is a type 1 transmembrane glycoprotein which belongs to the Delta/Serrate/Jagged Family of Notch receptor ligands
• The Notch family of transmembrane receptors and their ligands play key roles in various developmental and postnatal processes by controlling cell-fate decisions
• Delta-Like Protein 4 is expressed by vascular endothelial cells within certain normal tissues and tumors
• It signals through Notch1 and Notch 4 Receptors and plays a critical role in vascular development and homeostasis
• Delta-Like Protein 4 expression is upregulated in response to vascular endothelial growth factor (VEGF) and regulates endothelial cell proliferation during vascular sprouting
• Delta-Like Protein 4 is also expressed by activated human monocytes and dendritic cells that have been stimulated with proinflammatory activators such as lipopolysaccharide
• Recent evidence suggests that Delta-Like Protein 4 may contribute to the T cell potential of CD34+ cells and to the growth of various tumors, and promote tumor cell infiltration
• During product development, the specificity of the purified MHD4-46 antibody (Cat
• No
• 564589) was confirmed by immunohistochemical staining of acetone-fixed frozen sections of human placenta
• Vascular endothelial cells were specifically stained (data not shown).