Ikaros Mouse anti-Human, Alexa Fluor 488, Clone: R32-1149, BD

Description

• The R32-1149 monoclonal antibody specifically binds to Ikaros, which is encoded by IKZF1 (IKAROS family zinc finger 1)
• Ikaros is also known as Lymphoid transcription factor LyF-1 (LYF1) and ZNFN1A1 [Zinc finger protein, subfamily 1A, 1 (Ikaros)]
• Ikaros belongs to the IKAROS family of zinc-finger transcription factors
• This DNA-binding transcription factor forms homodimers and heterodimers with other IKAROS family members
• It is involved in the development of lymphoid tissues and remains abundantly expressed in the thymus and by cells within peripheral lymphoid tissues
• Ikaros functions in the maturation, differentiation, and homeostasis of various hematopoietic cells including T lymphocytes, B cells, NK cells, and neutrophils
• Ikaros regulates the expression of a number of genes including various genes expressed during early stages of B- and T-cell development
• Several alternatively-spliced human Ikaros isoforms have been described
• Abnormal expression of different Ikaros isoforms has been associated with hematologic malignancies
• Flow cytometric analysis of 293F cells transfected with members of the IKAROS family has demonstrated that clone R32-1149 is negative on Helios, Aiolos, and Eos transfectants.