COX-2 Mouse anti-Human, PE, Clone: AS67, BD

Description

• The AS67 monoclonal antibody specifically binds to Cyclooxygenase-2 (COX-2/COX2) which is also known as, Prostaglandin G/H synthase 2 (PGHS-2)
• The COX-2 enzyme is encoded by the PTGS2 gene, Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) and exists as a homodimer that is located on the lumenal surface of the endoplasmic reticulum and on the inner and outer membranes of the nuclear envelope
• COX-2 catalyzes the conversion of arachidonic acid into prostaglandin H2 (PGH2)
• Specific prostaglandin synthases then convert the PGH2 intermediate into various biologically active prostanoids, including Prostaglandin E2 (PGE2) and Thromboxane A2 (TXA2)
• COX-2 expression is not detected in most tissues under physiological conditions
• However, COX-2 expression is rapidly upregulated during the course of inflammation, following cellular stresses, and in response to growth factors, tumor promoters, hormones, bacterial endotoxins, and inflammatory cytokines, eg, Interleukin-1α (IL-1α)
• C OX-2 can be induced in a number of cell types, including fibroblasts, endothelial cells, monocytes, ovarian follicles and mesenchymal stromal cells
• Although COX-2 is structurally homologous to Cyclooxygenase-1 (COX-1), the AS67 antibody does not crossreact with recombinant human COX-1 protein as tested by immunoassay.