BDB566358
IL-17A Mouse anti-Human, Brilliant Violet 750, Clone: N49-653, BD
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB566358-Each-of-1 | In Stock | ₹ 33,197.28 |
BDB566358 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 33,197.28
GST (18%): ₹ 5,975.51
Total Price: ₹ 39,172.79
Antigen
IL-17A
Clone
N49-653
Conjugate
Brilliant Violet 750
Gene Alias
IL17, IL-17, CTLA8, Cytotoxic T-lymphocyte-associated serine esterase 8
Immunogen
Human IL-17A Recombinant Protein
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG1 κ
Description
- Human IL-17A, also known as IL-17, is a proinflammatory cytokine that is encoded by the IL17A gene in chromosome 6
- IL-17A is produced as a disulfide-linked homodimer comprised of two mature 136-amino acid polypeptides
- It is a member of the IL-17 family of structurally related cytokines, designated IL-17A through IL-17F
- Activated memory T cells, especially Th17 cells (specialized IL-17A-producing CD4+ T cells distinct from Th1 and Th2 cells) produce IL-17 and provide protective immunity against pathogens
- Activated CD8+ T cells, T cells, NK cells and neutrophils can also be activated to produce IL-17A
- IL-17A binds to and exerts its biological activity through IL-17 receptors (IL-17R) that are expressed by a variety of target cells including fibroblasts, epithelial and endothelial cells, monocytes/macrophages and mast cells
- The ubiquitous IL-17R expression pattern may explain the broad tissue responsiveness to IL-17
- IL-17 induces stromal cells to secrete cytokines and chemokines involved in inflammatory and hematopoietic processes
- For example, IL-17 induces fibroblasts to produce IL-6, IL-8, G-CSF and express increased surface ICAM-1
- The N49-653 antibody reacts with human IL-17A
- The antibody was conjugated to BD Horizon BV750 which is part of the BD Horizon Brilliant™ Violet family of dyes
- This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 750nm
- BD Horizon Brilliant BV750 can be excited by the violet laser (405 nm) and detected with a 750/30 nm filter with a 740 nm long pass
- Due to spectral differences between labeled cells and beads, using BD™ CompBeads can result in incorrect spillover values when used with BD Horizon BV750 reagents
- Therefore, the use of BD CompBeads or BD CompBeads Plus to determine spillover values for these reagents is not recommended
- BV750
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Antigen: IL-17A
Clone: N49-653
Conjugate: Brilliant Violet 750
Gene Alias: IL17, IL-17, CTLA8, Cytotoxic T-lymphocyte-associated serine esterase 8
Immunogen: Human IL-17A Recombinant Protein
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG1 κ
Antigen:
IL-17A
Clone:
N49-653
Conjugate:
Brilliant Violet 750
Gene Alias:
IL17, IL-17, CTLA8, Cytotoxic T-lymphocyte-associated serine esterase 8
Immunogen:
Human IL-17A Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ
Antigen: TNF
Clone: MAb11
Conjugate: Brilliant Violet 750
Gene Alias: Tumor necrosis factor alpha, TNF-a, TNF-α, TNFSF2, Cachectin
Immunogen: Recombinant Human TNF
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype: IgG1 κ
Antigen:
TNF
Clone:
MAb11
Conjugate:
Brilliant Violet 750
Gene Alias:
Tumor necrosis factor alpha, TNF-a, TNF-α, TNFSF2, Cachectin
Immunogen:
Recombinant Human TNF
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Baboon, Cynomolgus, Human, Rhesus Monkey
Isotype:
IgG1 κ
Antigen: Mouse IgG1, κ Isotype Control
Clone: X40
Conjugate: Brilliant Violet 750
Gene Alias: IgG1 kappa Isotype Control
Immunogen: Keyhole limpet hemocyanin (KLH)
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: __
Regulatory Status: RUO
Target Species: __
Isotype: IgG1 κ
Antigen:
Mouse IgG1, κ Isotype Control
Clone:
X40
Conjugate:
Brilliant Violet 750
Gene Alias:
IgG1 kappa Isotype Control
Immunogen:
Keyhole limpet hemocyanin (KLH)
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
RUO
Target Species:
__
Isotype:
IgG1 κ
Antigen: Rat IgG2a, κ Isotype Control
Clone: R35-95
Conjugate: Brilliant Violet 750
Gene Alias: Rat IgG2a kappa Isotype Control
Immunogen: Mouse Pooled Immunoglobulin
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: __
Regulatory Status: RUO
Target Species: __
Isotype: IgG2a κ
Antigen:
Rat IgG2a, κ Isotype Control
Clone:
R35-95
Conjugate:
Brilliant Violet 750
Gene Alias:
Rat IgG2a kappa Isotype Control
Immunogen:
Mouse Pooled Immunoglobulin
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
__
Regulatory Status:
RUO
Target Species:
__
Isotype:
IgG2a κ