PTP1C/SHP1 Mouse, Unlabeled, Clone: 52, BD

Description

• PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells
• It contains two N-terminal SH2 domains and a C-terminal phosphatase domain
• While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates
• This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors
• Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells
• Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway
• Host Species: Mouse Clone: 52 Isotype: IgG1 Species Reactivity: Human Immunogen: Human PTP1C aa.
• 492-597 Formula Weight [Chemical]: 68kDa Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting