E-Cadherin Mouse, Unlabeled, Clone: 36/E-CADHERIN, BD

Description

• E-Cadherin is a 120-kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells
• There it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins
• In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation
• Its association with catenins is necessary for cell-cell adhesion
• These E-cadherin/catenin complexes associate with cortical actin bundles at both the zonula adherens and the lateral adhesion plaques
• Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties
• E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas
• Increased expression of E-Cadherin in these cells reduces invasiveness
• Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression
• The 36/E-Cadherin monoclonal antibody recognizes the cytoplasmic domain of E-Cadherin, regardless of phosphorylation status
• The peptide immunogen was generated from human E-Cadherin aa
• 735-883
• Note: Investigators are advised that this antibody has some degree of cross-reactivity to P-Cadherin.