Rap1 Mouse, Unlabeled, Clone: 3, BD

Description

• Rap1 is a member of the large Ras superfamily of low molecular weight GTP/GDP binding proteins
• Like Ras, the Rap proteins cycle between a GDP-bound inactive form and a GTP-bound active form
• Since Ras and Rap have the same amino acid sequence in their putativeeffector domain (aa
• 32-40), it seems likely that they perform either similar or antagonistic functions
• Rap1A and Rap1B are highly homologous proteins, differing in only 9 of their 184 amino acids
• Overexpression of Rap1A (also known as Krev-1) causes reversion of the phenotype of a Ki-Ras-transformed cell line
• In vitro, Rap1 can compete efficiently with p21ras for interaction with Ras-GAP
• Though they appear to have similar activities, Rap1 and Ras differ in their cellular localization
• Ras is found on the inner surface of the plasma membrane while Rap1 is associated with the Golgi
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.