PSD-95 Mouse, Unlabeled, Clone: 16, BD

Description

• PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS
• Possible functions for the PSD include regulation and aggregation of receptors,structural stabilization of the synaptic junction, and transduction of signals from membrane receptors
• Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93
• PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS(nNOS or bNOS), and other proteins
• PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains
• nNOS, which is concentrated in synaptic junctions, also contains a PZD domain
• PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin
• This antibody is routinely tested by western blot analysis
• Other applications were tested in BD Biosciences Pharmingen during antibody development only or reported in the literature.