Sec8 Mouse, Unlabeled, Clone: 14, BD

Description

• Signal transmission between neurons is regulated by the release of neurotransmitters at the synapse
• This process, which is controlled by a complex pathway of membrane trafficking in the presynaptic nerve terminal, leads to membrane fusion and neurotransmitter secretion
• Sec8 is a hydrophilic protein of 975 amino acids that is highly expressed in brain and kidney
• It is homologus with the yeastsecretory protein, Sec8p
• In yeast, Sec8 is essential for the Golgi-to-plasma membrane traffic of proteins during constitutive secretion
• In rat brain, Sec8 colocalizes with Rab3 and Syntaxin-1a, two important proteins that regulate the fusion of the synaptic vesicle to the plasma membrane
• The primary structure of Sec8, a coiled-coil domain (residues 34-99), is commonly found in other proteins important in secretory pathways
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.