XIAP Mouse, Unlabeled, Clone: 48, BD

Description

• Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of multicellular organisms
• Viruses depend on the biosynthetic machinery of their host cell for the production of progeny and survival
• Therefore, many viruses encode proteins that protect the cell from apoptosis
• hILP ( h uman I AP- l ike p rotein) is a human homologue of the viral IAP ( I nhibitor of A poptosis P rotein)
• hILP is a widely expressed cytoplasmic protein of 497 amino acids with three BIR (Baculovirus IAP repeats) domains and a C-terminal RING finger domain
• hILP-transfected cells are protected against the apoptotic effects of Sindbis virus infection and ICE (interleukin-1 β; converting enzyme) expression
• This product is sold under license from Aegera Therapeutics, Inc
• This antibody is routinely tested by western blot analysis
• Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.