CaM Kinase II Mouse, Unlabeled, Clone: 45, BD

Description

• Ca 2+ ;/calmodulin-dependent protein kinase II (CaM kinase II) is a multifunctional Ser/Thr kinase that regulates a number of cellular functions in response to increased intracellular Ca 2+ ;
• CaM kinase II is widely distributed, but is predominantly expressed in brain
• It is involved in the regulation of neuronal functions such as neurotransmitter synthesis, neurotransmitter release, long-term potentiation, and formation of spatial learning
• Neuronal CaM kinase II contains heteromers of two major subunits, α and β, at a ratio of 2:1 and homomers of α subunits
• Each subunit has N-terminal ATP-binding and catalytic/regulatory domains and a C-terminal association domain
• The regulatory domain consists of the autoinhibitory and calmodulin-binding sites
• Assembly of the association domains of multiple subunits positions the regulatory domains for intersubunit autophosphorylation
• After binding Ca 2+ ;/calmodulin, CaM kinase II undergoes rapid autophosphorylation of the α and β subunits, which results in a substantial increase in its affinity for Ca 2+ ;/calmodulin
• Host Species: Mouse Clone: 45 Isotype: IgG1 Species Reactivity: Rat Immunogen: Rat CaM Kinase IIα aa
• 448-460 Formula Weight [Chemical]: 52kDa Immunofluorescence, Immunohistochemistry, Western Blotting