CD105 (Endoglin) Mouse anti-Human, Unlabeled, Clone: 35, BD

Description

• Endoglin (CD105), a major glycoprotein of human vascular endothelium, is a type I integral membrane protein with a large extracellular region, a hydrophobic transmembrane region, and a short cytoplasmic tail
• It also contains an RGD tripeptide that may be important for cellular adhesion
• There are two forms of endoglin (S-endoglin and L-endoglin) that differ in the length of their cytoplasmic tails
• However, the isoforms may have similar functional activity
• When overexpressed in fibroblasts, both form disulfide-linked homodimers via their extracellular domains
• Endoglin binds TGF-β1 and TGF-β3 by associating with TGF-β type II receptor and binds BMP-7 by associating with activin type II receptor
• Thus, endoglin is an accessory protein of multiple TGF-β superfamily kinase receptor complexes
• Loss of function mutations in the human endoglin gene cause hereditary hemorrhagic telangiectasia, which is characterized by vascular malformations
• Deletion of endoglin in mice leads to death due to defective vascular development
• Thus, endoglin is an endothelial specific cell surface protein that may regulate angiogenesis through interactions with TGF-β superfamily kinase receptors
• Host Species: Mouse Clone: 35 Isotype: IgG1 κ Species Reactivity: Human Immunogen: Human S-Endoglin aa
• 24-144 Formula Weight [Chemical]: 95kDa Immunofluorescence, Western Blotting