BDB611327
Topo IIα Mouse anti-Human, Unlabeled, Clone: 31, BD
Manufacturer: BD Biosciences
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB611327-Each-of-1 | In Stock | ₹ 45,218.46 |
BDB611327 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,218.46
GST (18%): ₹ 8,139.323
Total Price: ₹ 53,357.783
Antigen
Topo IIα
Classification
Monoclonal
Concentration
250μg/mL
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen
Human Topo IIα aa. 1245-1361
Quantity
150 μg
Research Discipline
Cell Biology
Target Species
Human
Isotype
IgG1
Applications
In vitro Assay, Western Blot
Clone
31
Conjugate
Unconjugated
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- Eukaryotic DNA topoisomerase II, a ubiquitous ATP-dependent type II topoisomerase, is an essential nuclear enzyme in DNA replication and transcription, chromatin segregation, and cell cycle progression
- These enzymes transiently break a pair of complementary strands in double-stranded DNA to form a gate for the passage of duplex DNA
- Two isoforms of DNA topoisomerase II have been identified, topo IIα and topo IIβ
- These have a high degree of homology, except for some divergence in the C-terminal region
- Both contain multiple bipartite nuclear localization sequences (NLS) that mediate their subnuclear localization
- Topo IIα levels rise during late S phase and peak in G2-M, whereas topo IIβ levels remain constant throughout the cell cycle
- In addition, topo IIα is expressed in proliferating cells, while topo IIβ is expressed in many tissues
- The exact role of these two isoforms during cell proliferation is not known, however the differences in cellular expression implicate different physiological roles
- Both isoforms may also be important targets for anticancer agents that exert cytotoxicity in proliferating cells via stabilization of a topo II-DNA complex
- Host Species: Mouse Clone: 31 Isotype: IgG1 Species Reactivity: Human Immunogen: Human Topo IIα aa
- 1245-1361 Formula Weight [Chemical]: 170kDa Immunofluorescence, Western Blotting
Compare Similar Items
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Antigen: Topo IIα
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Human Topo IIα aa. 1245-1361
Quantity: 150 μg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1
Applications: In vitro Assay, Western Blot
Clone: 31
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Topo IIα
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Human Topo IIα aa. 1245-1361
Quantity:
150 μg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1
Applications:
In vitro Assay, Western Blot
Clone:
31
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: PI3-Kinase C2β
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Human PI3-Kinase C2β aa. 16-209
Quantity: 50 μg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG1
Applications: Western Blot
Clone: 22
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
PI3-Kinase C2β
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Human PI3-Kinase C2β aa. 16-209
Quantity:
50 μg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Western Blot
Clone:
22
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: NPAT
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Human NPAT aa. 681-803
Quantity: 50 μg
Research Discipline: Cell Biology
Target Species: Human
Isotype: IgG2b
Applications: Western Blot
Clone: 27
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
NPAT
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Human NPAT aa. 681-803
Quantity:
50 μg
Research Discipline:
Cell Biology
Target Species:
Human
Isotype:
IgG2b
Applications:
Western Blot
Clone:
27
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: STRAP
Classification: Monoclonal
Concentration: 250μg/mL
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen: Mouse STRAP aa. 42-154
Quantity: 50 μg
Research Discipline: Cell Biology
Target Species: Human, Rat
Isotype: IgG1
Applications: Western Blot
Clone: 22
Conjugate: Unconjugated
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
STRAP
Classification:
Monoclonal
Concentration:
250μg/mL
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Immunogen:
Mouse STRAP aa. 42-154
Quantity:
50 μg
Research Discipline:
Cell Biology
Target Species:
Human, Rat
Isotype:
IgG1
Applications:
Western Blot
Clone:
22
Conjugate:
Unconjugated
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.