DEK Mouse anti-Human, Unlabeled, Clone: 2, BD

Description

• The (6;9) chromosomal translocation is associated with acute myelogenousleukemia (AML) and fuses the dek and can genes
• This results in expression of the oncogenic DEK-CAN fusion protein, consisting of the N-terminal two-thirds of DEK and the C-terminal two-thirds of CAN
• Although, on its own, DEK exhibits anti-oncogenic properties, the DEK-CAN chimera appears to be oncogenic
• DEK is a nuclear protein with a calculated molecular weight of 42-43 kD, that can be observable at 50 kD, and reportedly exhibits no substantial homology to any known protein sequences
• Although it contains 42% charged amino acids and multiple acidic sequences, specific structural features have yet to be identified
• In addition to its involvement in AML, DEK is associated with several disease states, such as juvenile rheumatoid arthritis where it is an autoantigen
• Efforts to define the cellular function of DEK led to its identification as the pets factor
• The peri-ets (pets) site is a TG-rich element between the two Elf-1 binding sites of the HIV-2 enhancer
• The pets site mediates transcriptional activation in response to T cell stimulation
• Thus, DEK is a site-specific DNA binding protein that functions in transcriptional regulation and signal transduction.