NPAT Mouse anti-Human, Unlabeled, Clone: 27, BD

Description

• Cyclins regulate transitions between cell cycle phases by acting as regulatory subunits of the cyclin-dependent kinases (cdk)
• The temporal expression of cyclins is tightly regulated and plays a critical role in controlling the enzymatic activity of the cdks
• Cyclin-dependent kinase 2 (Cdk2) is a member of a family of cdc2-related cell cycle protein kinases
• Cdk2 is expressed earlier in the cell cycle than cdc2 and forms complexes with cyclins A, E, D1, and D3
• It is not known if the D cyclins can form active complexes with Cdk2
• Cyclin E-Cdk2 kinase is active in the G1 and S phases of the cell cycle and is important, as is Cyclin A-Cdk2, for the progression from G1 to S phase
• One substrate for cyclin E-Cdk2 is a Nuclear Protein mapped to the Ataxia Telangiectasia locus, NPAT
• This protein associates with cyclin E-Cdk2 and can be phosphorylated by Cdk2
• NPAT protein levels peak at the G1/S boundary and overexpression of NPAT accelerates S phase entry, especially after coexpression of cyclin E-Cdk2
• Thus, NPAT is a substrate of cyclin E-Cdk2 that may mediate G1 to S phase transition
• Host Species: Mouse Clone: 27 Isotype: IgG2b Species Reactivity: Human Immunogen: Human NPAT aa
• 681-803 Formula Weight [Chemical]: 210kDa Immunofluorescence, Western Blotting