Syntaxin 8 Mouse, Unlabeled, Clone: 48, BD

Description

• Eukaryotic protein trafficking involves the packaging of molecules into membranous vesicles that bud from a donor compartment, travel to a specific destination, fuse, and release their components into an acceptor compartment
• Recognition between vesicle and acceptor membrane is mediated by the pairing of the integral membrane SNARE proteins
• The stable interaction between vesicle proteins (v-SNAREs) and target proteins (t-SNAREs) juxtaposes the membranes and results in an activated docking state and/or membrane fusion
• The syntaxin protein family contains a number of members that serve as functional t-SNAREs
• One member of this family, syntaxin 8, has two coiled-coil domains, one in the N-terminus and one toward the C-terminus
• The C-terminal domain is homologous to a similar domain in syntaxin 6 and is predicted to interact in the formation of SNARE complexes, while a hydrophobic domain in the C-terminus may be involved in membrane anchoring
• Syntaxin-8 is ubiquitously expressed, but is present at high levels in the heart and localizes specifically to the ER
• Thus, syntaxin-8 is a t-SNARE that is thought to be involved in the early secretory pathway of many different cell types
• Immunofluorescence, Western Blotting