CD9 Rat anti-Mouse, Brilliant Violet 510, Clone: KMC8 (also known as KMC 8), BD Optibuild™

Description

• The KMC8 monoclonal antibody specifically binds to CD9 which is also known as Tetraspanin-29 (Tspan29)
• CD9 is a 24-kDa member of the transmembrane 4 superfamily, also called the tretraspanin family
• In the mouse, CD9 is present on bone marrow myeloid cells, stromal cells, and megakaryocyte-committed progenitors; subsets of peripheral T and B lymphocytes; and neutrophils, platelets, dendritic cells, and bone marrow-derived macrophages
• CD9 has been found to be associated with integrins and other cell-surface receptors
• It appears to play roles in signal transduction and in regulating cellular adhesive properties
• CD9 can also reportedly participate in T-cell costimulation and induction of apoptosis
• The KMC8 antibody reportedly blocks certain CD9 functions and activates macrophages
• The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 405-nm and Em Max at 510-nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50-nm) filter set
• BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser.