HLA-A2 Mouse anti-Human, Brilliant Violet 711, Clone: BB7.2, BD Optibuild™

Description

• The monoclonal antibody BB7.2 specifically binds to the α subunit of the human leukocyte antigen-A2 (HLA-A2), a class I molecule of the major histocompatibility complex (MHC)
• The MHC gene locus encodes a group of highly polymorphic, cell-surface proteins that play a broad role in the immune response to protein antigens
• MHC molecules bind and present small antigenic protein fragments to antigen-specific receptors expressed by T cells (TCR)
• Human ( human leukocyte antigen /HLA) MHC molecules are comprised of two major classes, MHC class I and class II
• Functionally, class I MHC molecules bind peptides derived from intracellular antigens (eg, viral and some bacterial antigens) which are specifically recognized by CD8+ T cells
• Class II MHC molecules bind antigens derived from pathogens multiplying in intracellular vesicles and ingested extracellular bacteria, both of which are recognized by CD4+ T cells
• TCR recognize processed peptides bound to the MHC as well as regions of the MHC molecule itself
• CD4 and CD8 accessory molecules strengthen the formation of the TCR-MHC complex through their interaction with non-polymorphic regions of the MHC molecule.