BDB742290
Notch2 Mouse anti-Human, Brilliant Violet 510, Clone: MHN2-25, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB742290-Each-of-1 | In Stock | ₹ 47,400.24 |
BDB742290 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,400.24
GST (18%): ₹ 8,532.043
Total Price: ₹ 55,932.283
Antigen
Notch2
Clone
MHN2-25
Conjugate
Brilliant Violet 510
Gene Alias
NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen
Human Notch2 Recombinant Protein
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Mouse
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Human
Isotype
IgG2a κ
Description
- The MHN2-25 monoclonal antibody specifically binds to an extracellular domain of human Notch2
- Notch2 is a type 1 transmembrane glycoprotein receptor and member of the Notch family that includes Notch1-Notch4
- Notch2 is cleaved in the Golgi and presents as a cell surface heterodimeric receptor
- The Notch2 receptor can bind to several membrane-bound ligands including Jagged1, Jagged2, Delta1 and Delta4
- Upon ligand binding, Notch2 undergoes proteolytic cleavage that results in the release of the Notch intracellular domain, NICD
- NICD translocates to the nucleus where it forms a transcriptional activator complex with various transcriptional factors
- These multimeric complexes either positively or negatively regulate the expression of multiple genes including those that orchestrate many facets of embryonic development and the subsequent functioning of multiple organ systems such as the hematopoietic, immune, cardiovascular, hepatic and renal systems
- Notch2 is expressed by cells of the lung and brain, as well as cells of the B lineage, thymocytes, and T cells
- Abnormalities in Notch2 expression may play a role in the development of B cell lymphomas
- The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
- With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
- BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
- BV510 is a polymer-based dye that is brighter than BD Horizon V500
- Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
Compare Similar Items
Show Difference
Antigen: Notch2
Clone: MHN2-25
Conjugate: Brilliant Violet 510
Gene Alias: NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen: Human Notch2 Recombinant Protein
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Antigen:
Notch2
Clone:
MHN2-25
Conjugate:
Brilliant Violet 510
Gene Alias:
NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen:
Human Notch2 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Antigen: Notch2
Clone: MHN2-25
Conjugate: Brilliant Violet 650
Gene Alias: NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen: Human Notch2 Recombinant Protein
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Antigen:
Notch2
Clone:
MHN2-25
Conjugate:
Brilliant Violet 650
Gene Alias:
NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen:
Human Notch2 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Antigen: Notch2
Clone: MHN2-25
Conjugate: Brilliant Ultraviolet 395
Gene Alias: NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen: Human Notch2 Recombinant Protein
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Human
Isotype: IgG2a κ
Antigen:
Notch2
Clone:
MHN2-25
Conjugate:
Brilliant Ultraviolet 395
Gene Alias:
NOTC2, AGS2, hN2, HJCYS, Neurogenic locus notch homolog protein 2
Immunogen:
Human Notch2 Recombinant Protein
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ
Antigen: H-2Kq
Clone: KH114
Conjugate: Brilliant Violet 421
Gene Alias: H-2Kq, H2-Kq, Histocompatibility-2Kq
Immunogen: B10.Q mouse skin graft and splenocytes
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
H-2Kq
Clone:
KH114
Conjugate:
Brilliant Violet 421
Gene Alias:
H-2Kq, H2-Kq, Histocompatibility-2Kq
Immunogen:
B10.Q mouse skin graft and splenocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ