Home Products Antibodies Primary Antibodies BDB742326
BDB742326

MIC A/B Mouse anti-Human, Brilliant Violet 711, Clone: 6D4, BD Optibuild™

Manufacturer: BD Biosciences

Select a Size

Pack Size SKU Availability Price
Each of 1 BDB742326-Each-of-1 In Stock ₹ 47,614.14

BDB742326 - Each of 1

₹ 47,614.14

In Stock

Quantity

1

Base Price: ₹ 47,614.14

GST (18%): ₹ 8,570.545

Total Price: ₹ 56,184.685

Antigen

MIC A/B

Clone

6D4

Conjugate

Brilliant Violet 711

Gene Alias

MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2

Immunogen

MICA transfected cells

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG2a κ

Description

  • The 6D4 monoclonal antibody specifically binds to the human MHC class I polypeptide-related sequence A (MICA, aka /PERB11.1) and B (MICB
  • aka /PERB11.2) proteins
  • These ñ70 kDa transmembrane glycoproteins are homologs of the major histocompatibility complex class I molecules although they lackassociation with β2 microglobulin
  • The MHC class I-related MICA and MICB chains are expressed by some gut epithelial cells in vivo
  • MICA and MICB expression by other epithelial cells and cell types, including fibroblasts and endothelial cells, is induced by stress, eg, stress caused by bacterial and viral infections, autoimmunity or cellular transformation
  • Epithelial cell expression of MICA and MICB has also been detected in transplanted kidneys and pancreas that show histological signs of rejection and or cellular injury
  • This suggests their potential role in transplant immunopathology
  • MICA and MICB are ligands for NKG2D (CD314), an activating receptor expressed by natural killer (NK) cells,γδ T cells,CD8+ andsome CD4+ αβ T cells
  • The 6D4 antibody reportedly blocks NKG2D-positive NK cell- and T cell-mediated cytotoxicity against MICA/B-positive target cells
  • The antibody was conjugated to BD Horizon™ BV711 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 711nm
  • BD Horizon BV711 can be excited by the violet laser and detected in a filter used to detect Cy™5.5 / Alexa Fluor™ 700-like dyes (eg, 712/20nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination
  • BV711 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 711 nm
  • This dye offers a very bright choice for the violet laser
  • Due to the excitation and emission characteristics of the acceptor dye, there may be moderate spillover into the Alexa Fluor™ 700 and PerCP-Cy5.5 detectors
  • BV711 will also have moderate spillover into the BD Horizon Brilliant™ Violet 786 detector.

Compare Similar Items

Show Difference

Img

BD Biosciences

BDB742326

--

Antigen:
MIC A/B
Clone:
6D4
Conjugate:
Brilliant Violet 711
Gene Alias:
MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2
Immunogen:
MICA transfected cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

Img

BD Biosciences

BDB742327

--

Antigen:
MIC A/B
Clone:
6D4
Conjugate:
Brilliant Violet 786
Gene Alias:
MHC class I polypeptide-related sequence A/B, PERB11.1/ PERB11.2
Immunogen:
MICA transfected cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

Img

BD Biosciences

BDB742345

--

Antigen:
IgM[b]
Clone:
AF6-78
Conjugate:
Brilliant Violet 605
Gene Alias:
Igh-6b
Immunogen:
C57BL/10 mouse splenocytes
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742357

--

Antigen:
CD49a
Clone:
SR84
Conjugate:
Brilliant Violet 421
Gene Alias:
Integrin α1, Integrin alpha-1, ITGA1, ITA1, VLA-1, VLA1
Immunogen:
P-Selectin IgG1 Fusion
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ