BDB742813
MAdCAM-1 Rat anti-Mouse, Brilliant Violet 510, Clone: MECA-367, BD Optibuild™
Manufacturer: BD Biosciences
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | BDB742813-Each-of-1 | In Stock | ₹ 34,052.88 |
BDB742813 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,052.88
GST (18%): ₹ 6,129.518
Total Price: ₹ 40,182.398
Antigen
MAdCAM-1
Clone
MECA-367
Conjugate
Brilliant Violet 510
Gene Alias
Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen
Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity
50 μg
Primary or Secondary
Primary
Content And Storage
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification
Monoclonal
Concentration
0.2mg/mL
Formulation
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species
Rat
Purification Method
Affinity Purified
Regulatory Status
RUO
Target Species
Mouse
Isotype
IgG2a κ
Description
- The MECA-367 monoclonal antibody specifically recognizes mucosal vascular addressin MAdCAM-1
- In the fetus and neonate, MAdCAM-1 is the predominant vascular addressin on the high endothelial venules (HEV) of peripheral lymph nodes
- In adult mice, MAdCAM-1 is preferentially expressed in mucosal lymphoid tissues and lamina propria; it is also expressed on sinus-lining cells in the spleen
- MAdCAM-1 expression is upregulated on the HEV of peripheral lymph nodes in adult NOD mice4 and is involved in the development of diabetes and insulitis
- Furthermore, there is evidence that IFN-γcan induce MAdCAM-1 expression in non-mucosal sites in adult mice
- MAdCAM-1 is a predominant ligand for integrinα4β7, a lymphocyte mucosal homing receptor, and a facultative ligand for CD62L (L-selectin)
- MECA-367 mAb binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro /and lymphocyte homing to Peyer's patch HEV in vivo /
- Source of the immunogen was endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes
- The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
- With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
- BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
- BV510 is a polymer-based dye that is brighter than BD Horizon V500
- Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
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Antigen: MAdCAM-1
Clone: MECA-367
Conjugate: Brilliant Violet 510
Gene Alias: Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen: Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
MAdCAM-1
Clone:
MECA-367
Conjugate:
Brilliant Violet 510
Gene Alias:
Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen:
Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ
Antigen: MAdCAM-1
Clone: MECA-367
Conjugate: Brilliant Violet 605
Gene Alias: Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen: Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
MAdCAM-1
Clone:
MECA-367
Conjugate:
Brilliant Violet 605
Gene Alias:
Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen:
Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ
Antigen: MAdCAM-1
Clone: MECA-367
Conjugate: Brilliant Violet 650
Gene Alias: Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen: Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
MAdCAM-1
Clone:
MECA-367
Conjugate:
Brilliant Violet 650
Gene Alias:
Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen:
Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ
Antigen: MAdCAM-1
Clone: MECA-367
Conjugate: Brilliant Violet 786
Gene Alias: Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen: Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity: 50 μg
Primary or Secondary: Primary
Content And Storage: Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification: Monoclonal
Concentration: 0.2mg/mL
Formulation: Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species: Rat
Purification Method: Affinity Purified
Regulatory Status: RUO
Target Species: Mouse
Isotype: IgG2a κ
Antigen:
MAdCAM-1
Clone:
MECA-367
Conjugate:
Brilliant Violet 786
Gene Alias:
Madcam1, MADCA, mucosal vascular addressin cell adhesion molecule 1
Immunogen:
Mouse endothelial cells from BALB/c mouse mesenteric and peripheral lymph nodes.
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Rat
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG2a κ