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BDB742994

Siglec-1 (CD169) Mouse anti-Human, Brilliant Violet 650, Clone: 7-239, BD Optibuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB742994-Each-of-1 In Stock ₹ 47,614.14

BDB742994 - Each of 1

₹ 47,614.14

In Stock

Quantity

1

Base Price: ₹ 47,614.14

GST (18%): ₹ 8,570.545

Total Price: ₹ 56,184.685

Antigen

Siglec-1 (CD169)

Clone

7-239

Conjugate

Brilliant Violet 650

Gene Alias

Sialoadhesin, SN, SIGLEC1, Siglec-1, Sialic acid-binding Ig-like lectin 1

Immunogen

Human Rhinovirus-infected Dendritic Cells

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG1 κ

Description

  • The 7-239 monoclonal antibody specifically binds to Sialic acid-binding Ig-like lectin 1 (Siglec-1), which is also known as Sialoadhesin (SN), or CD169
  • Siglec-1 is a type I transmembrane glycoprotein that belongs to the Siglec family within the Ig superfamily
  • This adhesion molecule especiallybinds to glycolipids and glycoproteins with terminal α-2 sialyl residues.Siglec-1 is expressed by macrophages and dendritic cells and serves as a cellular interaction molecule
  • Its expression can be upregulated by cells in response to type II collagen, or to cytokines including interferons, and tumor necrosis factor
  • Siglec-1 plays roles in endocytosis, hematopoiesis, and leucocyte migration
  • It mediates macrophage binding to various cell types including developing and mature leucocytes
  • Siglec-1 that is expressed by dendritic cells can also bind HIV-1 and may mediate viral transfer to bystander CD4+ T cells
  • Several Siglec-1 counter-receptors have been described including CD43, CD206, and CD227 which are expressed by T cells, macrophages, or breast cancer cells, respectively
  • The 7-239 antibody reportedly blocks Siglec-1 functions in some cellular assay systems
  • The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm
  • BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination
  • BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm
  • Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
  • BV650 will have moderate spillover into the BD Horizon™ BV711 detector.

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Img

BD Biosciences

BDB742994

--

Antigen:
Siglec-1 (CD169)
Clone:
7-239
Conjugate:
Brilliant Violet 650
Gene Alias:
Sialoadhesin, SN, SIGLEC1, Siglec-1, Sialic acid-binding Ig-like lectin 1
Immunogen:
Human Rhinovirus-infected Dendritic Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742996

--

Antigen:
Siglec-1 (CD169)
Clone:
7-239
Conjugate:
Brilliant Violet 786
Gene Alias:
Sialoadhesin, SN, SIGLEC1, Siglec-1, Sialic acid-binding Ig-like lectin 1
Immunogen:
Human Rhinovirus-infected Dendritic Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742997

--

Antigen:
Siglec-1 (CD169)
Clone:
7-239
Conjugate:
Brilliant Ultraviolet 395
Gene Alias:
Sialoadhesin, SN, SIGLEC1, Siglec-1, Sialic acid-binding Ig-like lectin 1
Immunogen:
Human Rhinovirus-infected Dendritic Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG1 κ

Img

BD Biosciences

BDB742998

--

Antigen:
Vβ 5.1, 5.2 T-Cell Receptor
Clone:
MR9-4
Conjugate:
Brilliant Violet 421
Gene Alias:
TCR Vβ5.1/5.2, Vβ5 T-cell receptor, T cell receptor beta 5
Immunogen:
Mouse T-Cell Hybridoma 2HB51.8
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Mouse
Isotype:
IgG1 κ