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BDB743307

CD71 Mouse anti-Human, Brilliant Violet 650, Clone: M-A712, BD Optibuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB743307-Each-of-1 In Stock ₹ 47,614.14

BDB743307 - Each of 1

₹ 47,614.14

In Stock

Quantity

1

Base Price: ₹ 47,614.14

GST (18%): ₹ 8,570.545

Total Price: ₹ 56,184.685

Antigen

CD71

Clone

M-A712

Conjugate

Brilliant Violet 650

Gene Alias

TFR, TFRC, Trfr, TfR1, Transferrin receptor protein 1

Immunogen

T-CLL and Jurkat Cells

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG2a κ

Description

  • The M-A712 monoclonal antibody specifically binds to CD71 which is also known as the transferrin receptor (TFR)
  • This type II transmembrane glycoprotein is expressed on cells as a disulfide-linked homodimer comprised of 95 kDa monomers
  • CD71 is expressed on activated lymphocytes, monocytes, macrophages, erythroid progenitors, brain endothelium, and most proliferating cells
  • CD71 is not expressed on resting lymphocytes and is upregulated during lymphocyte responses to antigens or mitogens
  • Through an endocytic pathway, the transferrin receptor mediates cellular iron uptake by binding and internalizing iron that is bound to transferrin
  • After releasing iron within the low pH endosomal environment, transferrin and its receptor can be recycled to the cell surface
  • The antibody was conjugated to BD Horizon™ BV650 which is part of the BD Horizon Brilliant™ Violet family of dyes
  • This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 650nm
  • BD Horizon BV650 can be excited by the violet laser and detected in a filter used to detect APC-like dyes (eg, 660/20nm filter)
  • Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
  • However, the spillover can be corrected through compensation as with any other dye combination
  • BV650 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 650 nm
  • Due to the excitation and emission characteristics of the acceptor dye, there will be spillover into the APC and Alexa Fluor™ 700 detectors
  • BV650 will have moderate spillover into the BD Horizon™ BV711 detector.

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BDB743307

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Antigen:
CD71
Clone:
M-A712
Conjugate:
Brilliant Violet 650
Gene Alias:
TFR, TFRC, Trfr, TfR1, Transferrin receptor protein 1
Immunogen:
T-CLL and Jurkat Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

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CD71
Clone:
M-A712
Conjugate:
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Gene Alias:
TFR, TFRC, Trfr, TfR1, Transferrin receptor protein 1
Immunogen:
T-CLL and Jurkat Cells
Quantity:
50 μg
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Classification:
Monoclonal
Concentration:
0.2mg/mL
Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Target Species:
Human
Isotype:
IgG2a κ

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Mouse
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IgG2a κ

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