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BDB751652

CD161 Mouse, anti-Human, R718, Clone: DX12, BD OptiBuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB751652-Each-of-1 In Stock ₹ 35,592.96

BDB751652 - Each of 1

₹ 35,592.96

In Stock

Quantity

1

Base Price: ₹ 35,592.96

GST (18%): ₹ 6,406.733

Total Price: ₹ 41,999.693

Antigen

CD161

Classification

Monoclonal

Conjugate

R718

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Refrigerate Upon Arrival

Applications

Flow Cytometry

Clone

DX12

Host Species

Mouse

Regulatory Status

RUO

Target Species

Human

Form

Liquid

Description

  • The DX12 monoclonal antibody specifically binds to human CD161 which is also known as Natural killer cell surface protein P1A (NKR-P1A)
  • CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene
  • CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B)
  • CD161 is a 80 kDa disulfide-linked homodimer, type II membrane glycoprotein
  • CD161 is expressed mostly on NK cell populations and on subsets of CD4+ and CD8+ αβ T cells, NKT cells and γδ T cells
  • Reports indicate that CD161 is expressed preferentially on CD45RO+ T cells, however, it can be found on a subset of thymocytes and fetal liver T cells
  • Its function has not been fully elucidated, but reports indicate that NKR-P1A may serve as a specific receptor for some NK cell targets
  • The DX12 antibody can reportedly inhibit spontaneous cytotoxicity mediated by certain NK cell clones.

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Monoclonal
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Primary or Secondary:
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Mouse
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RUO
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