CCR2 (CD192) Mouse, anti-Human, R718, Clone: LS132.1D9, BD OptiBuild™

Description

• The LS132.1D9 (aka, 1D9) monoclonal antibody specifically recognizes C-C chemokine receptor type 2 (CCR2 or CC-CKR-2) which is also known as CD192, CKR2, CMKBR2, or Monocyte chemoattractant protein 1 receptor (MCP-1 Receptor or MCP-1-R)
• CCR2 (CD192) is a seven-transmembrane, G-protein-coupled, glycoprotein receptor that belongs to the beta chemokine receptor family
• It is expressed on basophils, monocytes/macrophages, dendritic cells, activated T cells and B cells
• CCR2 (CD192) serves as a receptor for Monocyte chemoattractant protein 1 (MCP-1/CCL2), MCP-2/CCL8, MCP-3/CCL7, and MCP-4/CCL13
• CD192 exists in two forms, CD192A and CD192B
• The two forms are derived from alternatively spliced variants of a single gene and differ at their intracellular C-terminal ends
• CD192 plays an important role in inflammatory responses including monocytic infiltration of tissues associated with certain diseases, eg, atherosclerosis, rheumatoid arthritis, and tumors.