CD21 Mouse, anti-Human, R718, Clone: 1048, BD OptiBuild™

Description

• CD21 is a 145 kDa transmembrane glycoprotein that is expressed on mature B cells, follicular dendritic cells, a subset of immature thymocytes and on some epithelial cells
• CD21 is also known as the C3d Receptor, Complement Receptor 2 (CR2), and the Epstein-Barr Virus receptor, (EBV-R)
• CD21 is part of a large signal-transduction complex that also includes CD19, CD81 and Leu13
• CR2 serves as a receptor for the activation fragments of complement component C3, i.e
• C3d, iC3d, and C3dg and C3d-bound antigens and plays a central role in the immune response by amplifying B-cell activation and proliferation
• CR2 is also the receptor for EBV by binding its surface glycoprotein gp350/220
• Anti-human CR2 hybridomas were generated from Cr2-/-mice (lacking the cr2 gene, that encodes CR2 and CR1 in mice) immunized with the recombinant protein representing the first two amino-terminal short consensus repeats (SRC) of human CR2, SCR1-2
• Both the C3d and EBV binding sites of hu CR2 were localized to these sites
• Clone 1048 has been reported to specifically react with CR2-expressing cells and to inhibit CR2 interactions with C3 fragments or the EBV surface protein, gp350/220.