CD282 Mouse, anti-Human, R718, Clone: 11G7, BD OptiBuild™

Description

• The 11G7 monoclonal antibody specifically binds to human CD282, which is also known as Toll-like receptor 2 (TLR2)
• CD282 is expressed on monocytes, granulocytes, and dendritic cells
• Toll-like receptors (TLRs) play a critical role in antimicrobial resistance
• Moreover, TLRs have been shown to activate a number of signal transduction pathways which lead to the induction of genes involved in host defense
• TLRs are type-1 transmembrane receptors characterized by the presence of extracellular leucine-rich repeat and intracellular Toll/IL-1 receptor domains
• At least 12 mammalian TLRs have been identified, each recognizing a distinct bacterial or viral pathogen-associated molecular pattern, termed PAMP
• Peptidoglycan from Gram-positive bacteria, lipoproteins and lipopeptides from several bacteria, glycophosphatidylinositol, lipoarabinomannan, porins, and zymosan from yeast have been reported to be the ligands for TLR2
• It has been reported that mAb 11G7 inhibits the production of inflammatory cytokines via certain TLR2 ligands including TLR2/TLR1 ligands, lipoarabinomannan and PAM3CSK4
• However, 11G7 antibody does not inhibit the production of inflammatory cytokines with zymosan, a TLR2/TLR6 ligand
• Please note that this application has not been tested at BD Biosciences Pharmingen.