CD243 Mouse, anti-Human, R718, Clone: UIC2, BD OptiBuild™

Description

• The UIC2 monoclonal antibody specifically binds to an extracellular epitope of CD243, which is also known as ATP-binding cassette subfamily B member 1 (ABCB1), Multidrug resistance protein 1 (MDR1), or P-glycoprotein 1
• CD243 is a transmembrane glycoprotein that spans the membrane 12 times
• CD243 acts as an ATP-dependent efflux pump for a large variety of lipophilic molecules and drugs
• This efflux activity has been suggested to lead to resistance to the drugs used in chemotherapy
• CD243 is expressed by epithelial and endothelial cells, and at low levels by T cells, B cells, NK cells, and hematopoietic stem cells
• It may be expressed at high levels by multidrug resistant (MDR) tumor cells
• The UIC2 antibody reportedly inhibited the efflux of CD243 substrates from MDR cells and increased the cytotoxicity of certain CD243-transported drugs
• The UIC2 antibody reportedly does not crossreact with mouse CD243.