CD18 Mouse, anti-Mouse, R718, Clone: GAME-46, BD OptiBuild™

Description

• The GAME-46 monoclonal antibody specifically binds to CD18
• CD18 is the common β2 integrin chain of LFA-1 (CD11a/CD18, αLβ2 integrin), Mac-1 (CD11b/CD18, αMβ2 integrin), and gp150, 95 (CD11c/CD18, αXβ2 integrin)
• Expression of CD18 is limited to leucocytes, where it is widely distributed in consort with each of the three integrin α chains (CD11a, CD11b, and CD11c)
• Among splenocytes, NK cells have the highest density of CD18, and T lymphocytes express a higher density than the remaining cells
• The β2 integrins are important mediators of leukocyte-endothelium interactions
• It has been reported that GAME-46 antibody blocks in vitro adhesion of LFA-1-expressing cells to the ligands ICAM-1, ICAM-2 and ICAM-3 and of Mac-1-expressing cells to ICAM-1, C3bi, and fibrinogen.