CD88 Mouse, anti-Mouse, R718, Clone: 20/70, BD OptiBuild™

Description

• The 20/70 monoclonal antibody specifically binds to CD88, which is also known as, Complement component 5a receptor 1 (C5ar1), C5a anaphylatoxin chemotactic receptor, or C5a receptor (C5aR)
• CD88 belongs to the rhodopsin family of seven-transmembrane G protein-coupled receptors and mediates its effects by binding to the complement activation product, C5a
• CD88 is expressed on leucocytes including, neutrophils, monocytes, macrophages, and eosinophils
• CD88 may also be expressed on alveolar epithelial cells, endothelial cells, neural stem cells, oligodendrocytes, and on parenchymal cells of lung, liver, kidney and heart
• Binding of the proinflammatory C5a anaphylatoxin to CD88 results in G-protein coupling and intracellular signal transduction that mediates intracellular calcium release, chemotaxis, degranulation, cytokine production, and superoxide anion production
• The 20/70 antibody can block binding of C5a to CD88 and thus inhibit its biological functions.