CD49b Mouse, anti-Mouse, R718, Clone: HMA2, BD OptiBuild™

Description

• The HMα2 antibody reacts with integrin α2 chain (CD49b), the 150-kDa transmembrane glycoprotein that non-covalently associates with the integrin β1 subunit (CD29) to form the integrin α2β1 complex known as VLA-2
• VLA-2, a receptor for collagen and laminin, is expressed on some splenic CD4+ T lymphocytes and NK-T cells, intestinal intraepithelial and lamina propria lymphocytes, splenic NK cells, epithelial cells, and platelets| but it is not on thymocytes or Peyer's-patch or lymphnode lymphocytes
• The expression of VLA-2 is upregulated on lymphocytes in response to mitogens
• The HMα2 antibody has been reported to partially block the interaction of T-cell blasts, but not NK cells, with collagen
• Purified HMα2 mAb blocks the staining of splenic NK cells by the anti-CD49b/Pan-NK Cells mAb DX5 (Cat
• No
• 553858, for the PE conjugate)
• Therefore, mAb HMα2 may be used like the DX5 mAb for identification of NK cells.