CD140a Mouse, anti-Human, R718, Clone: α R1, BD OptiBuild™

Description

• The αR1 monoclonal antibody specifically binds to the human platelet derived growth factor (PDGF) receptor α (PDGFRα), also known as CD140a
• CD140a is a 170 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes
• PDGF receptors α and β are single glycoproteins with intracellular tyrosine kinase domains
• They are structurally similar to the M-CSF receptor and CD117 (c-kit)
• Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells
• PDGF plays a role in wound healing and it also acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils
• Functional PDGF is secreted in disulfide linked, homodimeric or heterodimeric forms comprised of A or B chains (PDGFAA, PDGF-BB or PDGF-AB)
• Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ
• The PDGFRα subunit binds both PDGF A and B chains, whereas the PDGFRβ subunit binds only PDGF B chains
• Although both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis
• The αR1 antibody is specific for PDGFRα and does not crossreact with PDGFRβ
• It immunoprecipitates human, monkey, rabbit, pig, dog and cat PDGFRα
• It does not recognize hamster, rat or mouse PDGFRα.