CD140b Mouse, anti-Human, R718, Clone: 28D4, BD OptiBuild™

Description

• Reacts with platelet derived growth factor (PDGF) receptor β, a 170-190 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes
• PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domains
• They are structurally similar to M-CSF receptor and CD117 (c-kit)
• Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells
• PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils
• Functional PDGF is secreted as a disulfide-linked dimer of A and B chains (PDGF-AA, PDGF-BB or PDGF-AB)
• Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ
• The PDGF receptor α-subunit binds both PDGF A and B chains, whereas the receptor β-subunit binds only PDGF B chain
• Both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis
• 28D4 is specific for PDGFRβ and does not cross-react with PDGFRα.