PI-16 Mouse, anti-Human, R718, Clone: CRCBT-02-001, BD OptiBuild™

Description

• The CRCBT-02-001 monoclonal antibody specifically binds to human CD364 which is also known as Peptidase inhibitor 16 (PI-16) or Protease inhibitor 16
• PI-16 is a glycophosphatidylinositol-linked, 436 amino acid surface glycoprotein
• It is a member of the cysteine-rich secretory protein (CRISP) family and is likewise known as CRISP9
• PI-16 is a putative serine protease inhibitor and can serve as a binding protein for PSP94 (prostate secretory protein of 94 amino acids) termed PSPBP
• Serum levels of PSP94 and PI-16 can reportedly serve as key targets for prostate cancer research
• PI-16 is highly expressed by the activated/memory, FoxP3-bright subsets of regulatory T cells
• PI-16-positive regulatory T cells expressed uniformly high levels of the chemokine receptors, CCR4 and CCR6, when compared with PI-16-negative T regulatory cells
• The results suggest that the CCR4+CCR6+ regulatory T cells are capable of homing to inflammatory sites and regulating effector T cells such as CCR4+CCR6+ Th17-like cells
• PI-16 is also expressed by subsets of memory CD4+ and CD8-bright T cells
• It is not expressed by B cells or monocytes.