CD49d Mouse, anti-Human, R718, Clone: 9F10, BD OptiBuild™

Description

• The 9F10 monoclonal antibody specifically reacts with the integrin α4 chain, that is expressed as a heterodimer with either of two β integrin subunits, β1 (CD29) or β7
• The α4β1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin
• The α4β7 integrin has a similar tissue distribution, except it is found on only a small subpopulation of thymocytes
• Integrin α4β7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1
• This antibody is useful for studies of the expression by and function of cells that express α4 chain-containing integrins
• This clone cross-reacts with a subset of peripheral blood lymphocytes, monocytes, and some granulocytes of baboon and both rhesus and cynomolgus macaque monkeys
• The distribution on leukocytes is similar to that observed with human peripheral blood leukocytes.