MilliporeSigma™ anti-Collagen Type II Clone: II-4C11,

Description

• Specifically detects Collagen Type II Clone: II-4C11 in Bovine, Human, Rabbit, Rat samples, and it is validated for Western Blotting Collagens are the major fibrous structural elements of cartilage, tendon, skin, bone, lung and blood vessels
• Their function is to hold cells together and thereby form discrete tissues
• Collagens form insoluble fibers that have a high intrinsic tensile strength
• Structurally, the collagens are composed of three polypeptide chains, αchains, which exist as three distinct subclasses each of which in turn is made up of numerous subtypes
• Type II collagen is a major component of cartilage
• It is translated as a pro-form which is then processed to yield the mature protein
• Collagen II can also be expressed in two different forms, IIA and IIB, as a result of alternate splicing involving the inclusion of exon
• The protein is synthesized primarily by chondrocytes and by certain cells in the eye, and exists as a trimer of α1(II) chains
• Mutations in collagen II have been documented in chondrodysplasias and ostoarthrosis.