Vitronectin Monoclonal Antibody (HV2), Invitrogen™

Description

• CSI 003-02-02 is highly specific for vitronectin
• There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin)
• CSI 003-02-02 is human-specific (no reactivity with cat, dog, cow, sheep, goat, pig, rabbit, horse)
• CSI 003-02-02 has been successfully used in ELISA, immunohistochemistry, and Western blotting techniques
• CSI 003-02-02 can be used to purify vitronectin from human plasma by affinity chromatography
• It can also be used to quantitatively affinity-deplete human plasma or serum of vitronectin
• It partially denatures vitronectin upon antibody binding
• It binds equally well to native and denatured vitronectin and can be used to quantitate vitronectin in human plasma in a sandwich ELISA with CSI 003-02-02
• It does not interfere with the binding of any known vitronectin ligands
• The epitope of CSI 003-02-02 is located in the connecting region
• Binding can be competed selectively by a peptide comprising aa 121-133
• NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL VTN is a member of the pexin family
• This protein is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors
• The protein is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.