FEPA5144205
ICAD Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | FEPA5144205-Each-of-1 | In Stock | ₹ 30,544.92 |
FEPA5144205 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 30,544.92
GST (18%): ₹ 5,498.086
Total Price: ₹ 36,043.006
Antigen
ICAD
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1676
Content And Storage
-20°C or -80°C if preferred
Isotype
IgG
Applications
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
4.67 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
O00273
Gene Symbols
DFFA
Immunogen
Recombinant Human DNA fragmentation factor subunit alpha protein (1-331AA)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Description
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
Compare Similar Items
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Antigen: ICAD
Classification: Polyclonal
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: -20°C or -80°C if preferred
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 4.67 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Recombinant Human DNA fragmentation factor subunit alpha protein (1-331AA)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
ICAD
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik, DFF, DFF1, DFF35, Dff45, DFF-45, Dffa, DNA fragmentation factor 45 kDa subunit, DNA fragmentation factor subunit alpha, DNA fragmentation factor, 45kDa, alpha polypeptide, DNA fragmentation factor, alpha subunit, H13, ICAD, ICAD-L, ICAD-S, Inhibitor of CAD, RP23-121D17.3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
4.67 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Recombinant Human DNA fragmentation factor subunit alpha protein (1-331AA)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: HMGN4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HMGN4
Gene Alias: high mobility group nucleosomal binding domain 4, high mobility group nucleosome-binding domain-containing protein 4, high mobility group protein N4, high-mobility group (nonhistone chromosomal) protein 17-like 3, high-mobility group protein 17-like 3, HMG17L3, HMGN4, NHC, Non-histone chromosomal protein, Non-histone chromosomal protein HMG-17-like 3
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 10473
Content And Storage: -20°C or -80°C if preferred
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin)
Concentration: 0.27 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O00479
Gene Symbols: HMGN4
Immunogen: Recombinant Human High mobility group nucleosome-binding domain-containing protein 4 protein (1-90AA)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
HMGN4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HMGN4
Gene Alias:
high mobility group nucleosomal binding domain 4, high mobility group nucleosome-binding domain-containing protein 4, high mobility group protein N4, high-mobility group (nonhistone chromosomal) protein 17-like 3, high-mobility group protein 17-like 3, HMG17L3, HMGN4, NHC, Non-histone chromosomal protein, Non-histone chromosomal protein HMG-17-like 3
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
10473
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin)
Concentration:
0.27 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O00479
Gene Symbols:
HMGN4
Immunogen:
Recombinant Human High mobility group nucleosome-binding domain-containing protein 4 protein (1-90AA)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: AES
Classification: Polyclonal
Conjugate: Unconjugated
Gene: TLE5
Gene Alias: Aes, AES-1, AES-2, AL024115, Amino enhancer of split, amino-terminal enhancer of split, Esp1, gp130-associated protein GAM, Grg, Grg5, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, related to Drosophila groucho, R-esp1, TLE family member 5, TLE family member 5, transcriptional modulator, TLE family member 5, amino-terminal enhancer of split, TLE5
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 166
Content And Storage: -20°C or -80°C if preferred
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin)
Concentration: 4.235 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q08117
Gene Symbols: AES, TLE5
Immunogen: Recombinant Human Amino-terminal enhancer of split protein (1-264AA)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
AES
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
TLE5
Gene Alias:
Aes, AES-1, AES-2, AL024115, Amino enhancer of split, amino-terminal enhancer of split, Esp1, gp130-associated protein GAM, Grg, Grg5, Grg-5, Groucho-related protein 5, Protein ESP1, Protein GRG, related to Drosophila groucho, R-esp1, TLE family member 5, TLE family member 5, transcriptional modulator, TLE family member 5, amino-terminal enhancer of split, TLE5
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
166
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin)
Concentration:
4.235 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q08117
Gene Symbols:
AES, TLE5
Immunogen:
Recombinant Human Amino-terminal enhancer of split protein (1-264AA)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid
Antigen: NMT2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: NMT2
Gene Alias: A930001K02Rik, AI605445, AU044698, fb40e03, Glycylpeptide N-tetradecanoyltransferase 2, glycylpeptide N-tetradecanoyltransferase 2 variant 3, glycylpeptide N-tetradecanoyltransferase 2 variant 4, hNMT-2, myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Nmt2, NMT2 protein, N-myristoyltransferase 2, peptide N-myristoyltransferase 2, Type II N-myristoyltransferase, wu:fb40e03
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9397
Content And Storage: -20°C or -80°C if preferred
Isotype: IgG
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation
Concentration: 2.7 mg/mL
Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O60551
Gene Symbols: NMT2
Immunogen: Recombinant Human Glycylpeptide N-tetradecanoyltransferase 2 protein (1-120AA)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Liquid
Antigen:
NMT2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
NMT2
Gene Alias:
A930001K02Rik, AI605445, AU044698, fb40e03, Glycylpeptide N-tetradecanoyltransferase 2, glycylpeptide N-tetradecanoyltransferase 2 variant 3, glycylpeptide N-tetradecanoyltransferase 2 variant 4, hNMT-2, myristoyl-CoA:protein N-myristoyltransferase 2, NMT 2, Nmt2, NMT2 protein, N-myristoyltransferase 2, peptide N-myristoyltransferase 2, Type II N-myristoyltransferase, wu:fb40e03
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9397
Content And Storage:
-20°C or -80°C if preferred
Isotype:
IgG
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation
Concentration:
2.7 mg/mL
Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O60551
Gene Symbols:
NMT2
Immunogen:
Recombinant Human Glycylpeptide N-tetradecanoyltransferase 2 protein (1-120AA)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Liquid