CD21/CD35 Monoclonal Antibody (7E9), Invitrogen™

Description

• The monoclonal antibody 7E9 recognizes mouse complement receptors type 1 (CR1) and 2 (CR2)
• The monoclonal antibody 7E9 does not inhibit rosette formation between 2PK3 cells and Crd-coated SRBC indicator cells
• CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen
• CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens
• CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions
• A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands
• CD35 encodes a membrane glycoprotein found on peripheral blood cells, glomerular podocytes, and follicular dendritic cells
• The protein is a receptor for complement components C3b and C4b and regulates the activity of the complement cascade
• Variation in this protein is the basis of the Knops blood group system
• The two most common alleles, F and S, differ by 8 exons and are thought to be the result of an unequal crossover event
• A secreted form of the protein present in plasma has been described, but its full length nature has not been determined.