FERMA549074

CD206 Monoclonal Antibody (15-2), Biotin, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 FERMA549074-Each-of-1 In Stock ₹ 43,250.58

FERMA549074 - Each of 1

₹ 43,250.58

In Stock

Quantity

1

Base Price: ₹ 43,250.58

GST (18%): ₹ 7,785.104

Total Price: ₹ 51,035.684

Antigen

CD206

Classification

Monoclonal

Concentration

100 μg/mL

Formulation

PBS with 0.1% BSA and 0.02% sodium azide

Gene Accession No.

P22897

Gene Symbols

Mrc1

Immunogen

Purified human mannose receptor from human placental tissue

Quantity

50 μg

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot

Clone

15-2

Conjugate

Biotin

Gene

Mrc1

Gene Alias

AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4

Host Species

Mouse

Purification Method

Protein G

Regulatory Status

RUO

Gene ID (Entrez)

4360

Content And Storage

4° C

Isotype

IgG1

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Description

  • The monoclonal antibody 15-2 prevents binding of glycoproteins including t-PA to MR
  • Detection of the MR with anti-MR monoclonal antibody 15-2 can substitute staining for mannose containing probes as labeled mannosylated BSA, a technique which is more cumbersome and less specific
  • CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors
  • CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells
  • CD206 is thought to play a role in the innate and adaptive immune response
  • CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons
  • CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta)
  • While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD)
  • CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing
  • The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs)
  • The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms
  • CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis
  • The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages
  • Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

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Show Difference

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Thermo Scientific

FERMA549074

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Antigen:
CD206

Classification:
Monoclonal

Concentration:
100 μg/mL

Formulation:
PBS with 0.1% BSA and 0.02% sodium azide

Gene Accession No.:
P22897

Gene Symbols:
Mrc1

Immunogen:
Purified human mannose receptor from human placental tissue

Quantity:
50 μg

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Western Blot

Clone:
15-2

Conjugate:
Biotin

Gene:
Mrc1

Gene Alias:
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4

Host Species:
Mouse

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
4360

Content And Storage:
4° C

Isotype:
IgG1

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FERMA549076

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Antigen:
Nectin 2

Classification:
Monoclonal

Concentration:
100 μg/mL

Formulation:
PBS with 1% BSA and 0.02% sodium azide

Gene Accession No.:
P32507

Gene Symbols:
NECTIN2

Immunogen:
Nectin

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Inhibition Assays, Western Blot

Clone:
502-57

Conjugate:
FITC

Gene:
NECTIN2

Gene Alias:
AI325026; AI987993; CD112; herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; MPH; Murine herpes virus entry protein B; murine herpesvirus entry protein B; nectin cell adhesion molecule 2; Nectin2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); poliovirus receptor-related protein 2; poliovirus sensitivity; PRR2; Pvr; Pvrl2; PVRR2; Pvs

Host Species:
Rat

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
19294

Content And Storage:
4° C, store in dark

Isotype:
IgG2a

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FERMA549078

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Antigen:
Ly-6G/Ly-6C

Classification:
Monoclonal

Concentration:
100 μg/mL

Formulation:
PBS with 0.1% BSA and 0.02% sodium azide

Gene Accession No.:
P0CW02, P0CW03, P35461

Gene Symbols:
Ly6c1, Ly6c2, Ly6g

Immunogen:
Purified BALB/c mouse neutrophils

Quantity:
50 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Form:
Liquid

Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Clone:
NIMP-R14

Conjugate:
Biotin

Gene:
Ly6g

Gene Alias:
AA682074; AA959465; Gr1; Gr-1; Granulocyte Marker; Ly6c; Ly-6C; Ly-6C.2; Ly6c1; Ly-6C1; Ly6c2; Ly-6C2; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6 complex, locus C2; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6C precursor (Ly-6C); lymphocyte antigen 6C1; Lymphocyte antigen 6C2; lymphocyte antigen 6G; Lymphocyte antigen Ly-6C; lymphocyte differentiation antigen; PML; PMN

Host Species:
Rat

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
100041546, 17067, 546644

Content And Storage:
4° C

Isotype:
IgG2b

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Antigen:
Ly-6G/Ly-6C

Classification:
Monoclonal

Concentration:
100 μg/mL

Formulation:
PBS with 1% BSA and 0.02% sodium azide

Gene Accession No.:
P0CW02, P0CW03, P35461

Gene Symbols:
Ly6c1, Ly6c2, Ly6g

Immunogen:
Purified BALB/c mouse neutrophils

Quantity:
100 μg

Primary or Secondary:
Primary

Target Species:
Mouse

Form:
Liquid

Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin)

Clone:
NIMP-R14

Conjugate:
FITC

Gene:
Ly6c2

Gene Alias:
AA682074; AA959465; Gr1; Gr-1; Granulocyte Marker; Ly6c; Ly-6C; Ly-6C.2; Ly6c1; Ly-6C1; Ly6c2; Ly-6C2; Ly6g; Ly-6G; ly-6G.1; lymphocyte antigen 6 complex, locus C; lymphocyte antigen 6 complex, locus C1; lymphocyte antigen 6 complex, locus C2; lymphocyte antigen 6 complex, locus G; lymphocyte antigen 6C precursor (Ly-6C); lymphocyte antigen 6C1; Lymphocyte antigen 6C2; lymphocyte antigen 6G; Lymphocyte antigen Ly-6C; lymphocyte differentiation antigen; PML; PMN

Host Species:
Rat

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
100041546, 17067, 546644

Content And Storage:
4° C, store in dark

Isotype:
IgG2b