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MABE182825

beta-Catenin, Rat anti-Human, Clone: mAb-Cat1, Millipore Sigma™

Manufacturer: Fischer Scientific

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Pack Size SKU Availability Price
Each of 1 MABE182825-Each-of-1 In Stock ₹ 16,456.61

MABE182825 - Each of 1

₹ 16,456.61

In Stock

Quantity

1

Base Price: ₹ 16,456.61

GST (18%): ₹ 2,962.19

Total Price: ₹ 19,418.80

Antigen

beta-Catenin

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

Purified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Symbols

CTNNB1;CTNNB;OK/sw-cl.35;PRO2286

Immunogen

BSA-conjugated linear peptide corresponding to 19 amino acids from the N-terminal region of human beta-catenin 1.

Quantity

25 μL

Research Discipline

Epigenetics & Nuclear Function

Gene ID (Entrez)

NP_001091679.1

Target Species

Human

Form

Purified

Applications

ChIP Assay, Dot Blot, Immunoprecipitation, Western Blot

Clone

mAb-Cat1

Dilution

Western Blotting Analysis: A representative lot detected beta-Catenin in Western Blotting applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).Immunoprecipitation Analysis: A representative lot immunoprecipitated beta-Catenin in Immunoprecipitation applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).Dot Blot Analysis: A representative lot detected beta-Catenin in Dot Blot applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824). Chromatin Immunoprecipitation Analysis (ChIP): A representative lot immunoprecipitated beta-Catenin in Chromatin Immunoprecipitation applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).

Gene Alias

beta-Catenin 1;Catenin beta-1

Host Species

Rat

Purification Method

Protein G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

This rat monoclonal antibody detects beta-catenin 1 unmodified and methylated or acetylated on lysine 49. It targets an epitope with in 19 amino acids from the N-terminal region.

Content And Storage

Stable for 1 year at 2-8°C from date of receipt.

Isotype

IgG1 κ

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Description

  • Anti-beta-Catenin, clone mAb-Cat1, Cat
  • No
  • MABE1828, is a highly specific rat monoclonal antibody that targets beta-catenin 1 and has been tested for use in Chromatin Immunoprecipitation (ChIP), Dot Blot, Immunoprecipitation, and Western Blottiing
  • Catenin beta-1 (UniProt: P35222; also known as beta-Catenin) is encoded by the CTNNB1 (also known as CTNNB, OK/SW-cl.35, PRO2286) gene (Gene ID: 1499) in human
  • Catenin beta-1 is a key downstream component of the canonical Wnt signaling pathway that participates in intercellular adhesion and Wnt-mediated transcriptional activation
  • In the absence of Wnt, it forms a complex with AXIN1, AXIN2, APC, CSNK1A1, and GSK-3 beta that promotes phosphorylation on N-terminal serine and threonine residues that leads to its subsequent degradation by the proteasome
  • In the presence of Wnt ligand, it is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, which leads to activation of Wnt responsive genes
  • O-glycosylation at serine 23 is reported to decreases its nuclear localization and transcriptional activity
  • Wnt/beta-catenin signaling is shown to be essential for embryonic stem cell (ESC) pluripotency and differentiation
  • In ESC beta-catenin is trimethylated on Lysine 49 by Ezh2 methyltransferase and this trimethylated form represses neuronal differentiation genes Sox1 and Sox3
  • Mutations in CTNNB1 gene are shown to cause colorectal cancers, medulloblastoma, and ovarian cancers
  • (Ref.: Hoffmeyer, K., et al
  • (2017)
  • Cell Reports 18(12); 2815-2824.

Compare Similar Items

Show Difference

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Fischer Scientific

MABE182825

--

Antigen:
beta-Catenin
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
CTNNB1;CTNNB;OK/sw-cl.35;PRO2286
Immunogen:
BSA-conjugated linear peptide corresponding to 19 amino acids from the N-terminal region of human beta-catenin 1.
Quantity:
25 μL
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_001091679.1
Target Species:
Human
Form:
Purified
Applications:
ChIP Assay, Dot Blot, Immunoprecipitation, Western Blot
Clone:
mAb-Cat1
Dilution:
Western Blotting Analysis: A representative lot detected beta-Catenin in Western Blotting applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).Immunoprecipitation Analysis: A representative lot immunoprecipitated beta-Catenin in Immunoprecipitation applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).Dot Blot Analysis: A representative lot detected beta-Catenin in Dot Blot applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824). Chromatin Immunoprecipitation Analysis (ChIP): A representative lot immunoprecipitated beta-Catenin in Chromatin Immunoprecipitation applications (Hoffmeyer, K., et. al. (2017). Cell Rep. 18(12):2815-2824).
Gene Alias:
beta-Catenin 1;Catenin beta-1
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rat monoclonal antibody detects beta-catenin 1 unmodified and methylated or acetylated on lysine 49. It targets an epitope with in 19 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ

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MABE1829100

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Antigen:
Acetyl β-Catenin (Lys49)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
BSA-conjugated linear peptide corresponding to 19 amino acids surrounding acetylated lysine 49 from human -catenin.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Dot Blot, Immunoprecipitation, Western Blot
Clone:
mAb-K49-Ac
Dilution:
__
Gene Alias:
__
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ

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Fischer Scientific

MABE182925

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Antigen:
Acetyl β-Catenin (Lys49)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rat monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
BSA-conjugated linear peptide corresponding to 19 amino acids surrounding acetylated lysine 49 from human -catenin.
Quantity:
25 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Dot Blot, Immunoprecipitation, Western Blot
Clone:
mAb-K49-Ac
Dilution:
__
Gene Alias:
__
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ

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MABE1870100

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Antigen:
TTC23L
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
Linear Peptide corresponding to 16 amino acids from the C-terminal region of human Tetratricopeptide repeat protein 23-like (TTC23L), isoform 1.
Quantity:
100 μg
Research Discipline:
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Gene ID (Entrez):
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Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Western Blot
Clone:
2A4
Dilution:
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Gene Alias:
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Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG1 κ