MABE188625
BMAL1 (ARNTL), Mouse anti-Mouse, Clone: B1BH2 , Millipore Sigma™
Manufacturer: Fischer Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE188625-Each-of-1 | In Stock | ₹ 16,456.61 |
MABE188625 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
BMAL1 (ARNTL)
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
ARNTL;BMAL1
Immunogen
MBP-conjugated recombinant fragment corresponding to 56 amino acids from the N-terminal region of chicken BMAL1.
Quantity
25 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_001001463
Target Species
Mouse
Form
Purified
Applications
ChIP Assay, Western Blot
Clone
B1BH2
Dilution
Chromatin Immunoprecipitation Analysis (ChIP): A representative lot detected BMAL1 (ARNTL) in Chromatin Immunoprecipitation applications (Yoshitane, H., et. al. (2014). Mol Cell Biol. 34(10):1776-87).Western Blotting Analysis: A representative lot detected BMAL1 (ARNTL) in Western Blotting applications (Yoshitane, H., et. al. (2009). Mol Cell Biol. 29(13):3675-86; Yoshitane, H., et. al. (2012). EMBO Rep. 13(5):455-61).
Gene Alias
Aryl hydrocarbon receptor nuclear translocator-like protein 1;BMAL1b';Brain and muscle ARNT-like 1
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone B1BH2 specifically detects Brain and muscle ARNT-like 1 (BMAL1). It targets an epitope within 56 amino acids from the N-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-BMAL1 (ARNTL), clone B1BH2, Cat
- No
- MABE1886, is a highly specific mouse monoclonal antibody that targets Brain and muscle ARNT-like 1 (BMAL1) and has been tested for use in Chromatin Immunoprecipitation (ChIP) and Western Blotting
- Aryl hydrocarbon receptor nuclear translocator-like protein 1 (UniProt: Q9I8T7; also known as BMAL1b', Brain and muscle ARNT-like 1, cBMAL1) is encoded by the ARNTL (also known as BMAL1) gene (Gene ID: 374115) in chicken
- BMAL1 is expressed in pineal gland and retina and displays maximum levels between ZT13 and ZT16 during light/dark cycle
- BMAL1 is a transcriptional activator that forms a core component of the circadian clock
- These components include ARNTL/BMAL1, CLOCK, NPAS2, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1, and CRY2
- CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2 form the positive limb of the feedback loop
- They act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes that are involved in key metabolic processes
- PER1/2/3 and CRY1/2, act as transcriptional repressors and form the negative limb of the feedback loop
- They interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity
- BMLA1 is highly expressed in the adult brain, skeletal muscle, and heart
- It shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription, and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer
- BMLA1 is reported to be phosphorylated upon dimerization with CLOCK and this phosphorylation enhances its transcriptional activity and reduces the stability of the CLOCK-ARNTL/BMAL1 heterodimer by promoting its degradation
- BMAL1 null-mice are reported to have reproductive problems, reduced locomotor activity, and premature aging.
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Antigen: BMAL1 (ARNTL)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: ARNTL;BMAL1
Immunogen: MBP-conjugated recombinant fragment corresponding to 56 amino acids from the N-terminal region of chicken BMAL1.
Quantity: 25 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_001001463
Target Species: Mouse
Form: Purified
Applications: ChIP Assay, Western Blot
Clone: B1BH2
Dilution: Chromatin Immunoprecipitation Analysis (ChIP): A representative lot detected BMAL1 (ARNTL) in Chromatin Immunoprecipitation applications (Yoshitane, H., et. al. (2014). Mol Cell Biol. 34(10):1776-87).Western Blotting Analysis: A representative lot detected BMAL1 (ARNTL) in Western Blotting applications (Yoshitane, H., et. al. (2009). Mol Cell Biol. 29(13):3675-86; Yoshitane, H., et. al. (2012). EMBO Rep. 13(5):455-61).
Gene Alias: Aryl hydrocarbon receptor nuclear translocator-like protein 1;BMAL1b';Brain and muscle ARNT-like 1
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone B1BH2 specifically detects Brain and muscle ARNT-like 1 (BMAL1). It targets an epitope within 56 amino acids from the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
BMAL1 (ARNTL)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
ARNTL;BMAL1
Immunogen:
MBP-conjugated recombinant fragment corresponding to 56 amino acids from the N-terminal region of chicken BMAL1.
Quantity:
25 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_001001463
Target Species:
Mouse
Form:
Purified
Applications:
ChIP Assay, Western Blot
Clone:
B1BH2
Dilution:
Chromatin Immunoprecipitation Analysis (ChIP): A representative lot detected BMAL1 (ARNTL) in Chromatin Immunoprecipitation applications (Yoshitane, H., et. al. (2014). Mol Cell Biol. 34(10):1776-87).Western Blotting Analysis: A representative lot detected BMAL1 (ARNTL) in Western Blotting applications (Yoshitane, H., et. al. (2009). Mol Cell Biol. 29(13):3675-86; Yoshitane, H., et. al. (2012). EMBO Rep. 13(5):455-61).
Gene Alias:
Aryl hydrocarbon receptor nuclear translocator-like protein 1;BMAL1b';Brain and muscle ARNT-like 1
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone B1BH2 specifically detects Brain and muscle ARNT-like 1 (BMAL1). It targets an epitope within 56 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ERR alpha
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: ESRRA, ERR1, ESRL1, NR3B1
Immunogen: His-tagged full length human recombinant Steroid hormone receptor ERR alpha (ERR1).
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: ChIP Assay, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 2ERR10
Dilution: __
Gene Alias: Steroid hormone receptor ERR1;Estrogen receptor-like 1;Estrogen-related receptor alpha;Nuclear receptor subfamily 3 group B member 1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone 2ERR10 is a mouse monoclonal antibody that detects human Steroid hormone receptor ERR alpha (ERR1).
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
ERR alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
ESRRA, ERR1, ESRL1, NR3B1
Immunogen:
His-tagged full length human recombinant Steroid hormone receptor ERR alpha (ERR1).
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
ChIP Assay, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
2ERR10
Dilution:
__
Gene Alias:
Steroid hormone receptor ERR1;Estrogen receptor-like 1;Estrogen-related receptor alpha;Nuclear receptor subfamily 3 group B member 1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone 2ERR10 is a mouse monoclonal antibody that detects human Steroid hormone receptor ERR alpha (ERR1).
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ERR alpha
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: ESRRA, ERR1, ESRL1, NR3B1
Immunogen: His-tagged full length human recombinant Steroid hormone receptor ERR alpha (ERR1).
Quantity: 25 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: ChIP Assay, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 2ERR10
Dilution: __
Gene Alias: Steroid hormone receptor ERR1;Estrogen receptor-like 1;Estrogen-related receptor alpha;Nuclear receptor subfamily 3 group B member 1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone 2ERR10 is a mouse monoclonal antibody that detects human Steroid hormone receptor ERR alpha (ERR1).
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
ERR alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
ESRRA, ERR1, ESRL1, NR3B1
Immunogen:
His-tagged full length human recombinant Steroid hormone receptor ERR alpha (ERR1).
Quantity:
25 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
ChIP Assay, ELISA, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
2ERR10
Dilution:
__
Gene Alias:
Steroid hormone receptor ERR1;Estrogen receptor-like 1;Estrogen-related receptor alpha;Nuclear receptor subfamily 3 group B member 1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone 2ERR10 is a mouse monoclonal antibody that detects human Steroid hormone receptor ERR alpha (ERR1).
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: XRCC5 (Ku86)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: XRCC5, G22P2
Immunogen: Full-length human recombinant DNA repair protein XRCC5 (Ku86).
Quantity: 100 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: N9C1
Dilution: __
Gene Alias: X-ray repair cross-complementing protein 5;86 kDa subunit of Ku antigen;ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;CTC box-binding factor 85 kDa subunit;CTC85;CTCBF;DNA repair protein XRCC5;Ku80;Ku86;Lupus Ku autoantigen protein p86;Nuclear factor IV;Thyroid-lupus autoantigen;TLAA;X-ray repair complementing defective repair in Chinese hamster cells 5
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: Clone N9C1 is a mouse monoclonal antibody that specifically detects DNA repair protein XRCC5.
Content And Storage: Stable for 1 year at 2 to 8°C from date of receipt.
Isotype: IgG1 λ
Antigen:
XRCC5 (Ku86)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
XRCC5, G22P2
Immunogen:
Full-length human recombinant DNA repair protein XRCC5 (Ku86).
Quantity:
100 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
N9C1
Dilution:
__
Gene Alias:
X-ray repair cross-complementing protein 5;86 kDa subunit of Ku antigen;ATP-dependent DNA helicase 2 subunit 2;ATP-dependent DNA helicase II 80 kDa subunit;CTC box-binding factor 85 kDa subunit;CTC85;CTCBF;DNA repair protein XRCC5;Ku80;Ku86;Lupus Ku autoantigen protein p86;Nuclear factor IV;Thyroid-lupus autoantigen;TLAA;X-ray repair complementing defective repair in Chinese hamster cells 5
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
Clone N9C1 is a mouse monoclonal antibody that specifically detects DNA repair protein XRCC5.
Content And Storage:
Stable for 1 year at 2 to 8°C from date of receipt.
Isotype:
IgG1 λ